I can't start the game, as soon as I begin the mouse begins leaving a trail wherever I move it, starting a new game will leave me at "SKYRIM" stuck on my screen, but still have sounds play.Are you trying this at the very start? It seems like it. Try it after some time in-game, unless whenever you press ESC that happens.
do you play in windowed or full screen
might be something to do with that maybe
Already done that.Try verifying your Skyrim game files from your Steam library it may work after that.